Enterokun Mild WOW 3.1 kg

It improves epithelial integrity since it is the preferred metabolic fuel of enterocytes, positively influencing cell proliferation, differentiation, and maturation (greater villi height and shallower crypt depth) and therefore facilitates nutrient absorption. Butyric acid also acts by reducing intestinal inflammation, through the reduction of oxidative damage to DNA and by inducing apoptosis in cells with DNA damage.

Maintains the function and integrity of the intestinal barrier at the level of tight junctions, thus preventing the entry of antigens, toxins, and pathogenic bacteria that cause inflammation.

They modulate the production of eicosanoids, with the eicosanoids resulting from the metabolism of omega 3 fatty acids being less stimulatory of the inflammatory response than those resulting from omega 6 fatty acids. Additionally, omega 3 fatty acids are precursors of resolvins and protectins, substances that counter-regulate inflammation, serving as agonists of endogenous anti-inflammatory mechanisms and acting significantly in the resolution of inflammation.

Improves the balance of the intestinal microbiota. Competition for nutrients, adhesion sites, and the production of antimicrobial substances (short-chain fatty acids, defensins, etc.) inhibit the proliferation of pathogenic bacteria while promoting the development of beneficial bacteria.

Prebiotic component, which means it resists digestion and reaches the colon intact where it serves as an energy source for beneficial bacteria (Lactobacillus spp, Bacteroides spp, and Bifidobacterium spp), thus stimulating their growth and/or activity. As a result of its fermentation, the production of toxic substances (ammonia and biogenic amines) decreases and the release of short-chain fatty acids (acetate, propionate, lactate, and butyrate) into the intestinal lumen increases, reducing the presence of pathogenic bacteria (E. coli and C. perfringens), thanks to the reduction of colonic pH.

It plays an important role in many biochemical reactions (including DNA synthesis and methionine synthesis from homocysteine), as well as in important enzymatic reactions in the citric acid cycle, where it acts as a cofactor. Hypocobalaminemia typically occurs when specific cobalamin receptors in the ileum are damaged as a consequence of inflammatory disease. Deficiency is accelerated by reduced cobalamin intake and ongoing gastrointestinal losses.