Dermakun WOW 3 kg

It suppresses the activity of tryptophan 2,3-dioxygenase, which is one of the key enzymes in the conversion of tryptophan to niacin. If tryptophan is converted to niacin, it is no longer available as a precursor of serotonin in the brain and, therefore, supplementation with vitamin B3 may reduce the “loss” of tryptophan due to nicotinic acid synthesis.

It is present throughout the body in the form of coenzyme A. Coenzyme A plays a fundamental role in the formation of a series of essential fatty acids and sterols. As such, it is important in the formation of lipids that make up the laminar components of the skin barrier.

It acts as a cofactor for carboxylase synthase enzymes. This group of enzymes catalyzes the biosynthesis of fatty acids, making this vitamin crucial in maintaining the health of the dermal barrier.

Inflammation generates a large amount of free radicals, which in turn accelerate the inflammatory process. Vitamin E is one of the most effective antioxidants to protect the oxidation of polyunsaturated fatty acids that make up cell membranes. It prevents lipid oxidation by eliminating peroxyl radicals before they can react with fatty acids or proteins of adjacent cell membranes.

It is the most potent reducing agent available to cells. Vitamin C regenerates the enzyme glutathione, neutralizes free radicals both intra- and extracellularly, and protects against free radical-mediated protein inactivation associated with oxidative neutrophil rupture.

Maintains the function and integrity of the intestinal barrier at the level of tight junctions, thus preventing the entry of antigens, toxins, and pathogenic bacteria that cause inflammation.

They modulate the production of eicosanoids, with the eicosanoids resulting from the metabolism of omega 3 fatty acids being less stimulatory of the inflammatory response than those resulting from omega 6 fatty acids. Additionally, omega 3 fatty acids are precursors of resolvins and protectins, substances that counter-regulate inflammation, serving as agonists of endogenous anti-inflammatory mechanisms and acting significantly in the resolution of inflammation.

Its anti-inflammatory effect is mediated by the inhibition of enzymes that mediate inflammatory processes such as COX-2, LOX, and iNOS, the production of cytokines like interferon gamma and tumor necrosis factor, and the activation of transcription factors such as NF-κB and AP-1.

Increases the bioavailability of curcumin (over 20 times), due to the inhibition it exerts on hepatic glucuronidation and intestinal metabolism of curcumin.